Methylamine hydrochloride → HCID 59275738, compound

HRID 1671945Notes

Reaction equation

HRID 1671945 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:19]=[C:18]([N+:20]([O-:22])=[O:21])[C:17]([C:23]4[CH:28]=[C:27]([C:29](=[O:40])[NH:30][C:31]5([C:34]6[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=6)[CH2:33][CH2:32]5)[CH:26]=[CH:25][C:24]=4[CH3:41])=[CH:16][C:11]=3[C:12]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.Cl.[CH3:43][NH2:44]>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:9][C:10]3[CH:19]=[C:18]([N+:20]([O-:22])=[O:21])[C:17]([C:23]4[CH:28]=[C:27]([C:29](=[O:40])[NH:30][C:31]5([C:34]6[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=6)[CH2:33][CH2:32]5)[CH:26]=[CH:25][C:24]=4[CH3:41])=[CH:16][C:11]=3[C:12]=2[C:13]([NH:44][CH3:43])=[O:15])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6364545Methylamine hydrochlorideHCID 59275776HCID 59275776, compound

Product 1

HCID 59275738HCID 59275738, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Prepared by the coupling of 2-(4-fluorophenyl)-5-(2-methyl-5-(1-phenylcyclopropylcarbamoyl)phenyl)-6-nitrobenzofuran-3-carboxylic acid with methylamine hydrochloride under the conditions as described. LC/MS were performed by using Shimadzu-VP instrument with UV detection at 220 nm and Waters Micromass. HPLC method: Solvent A=10% MeOH-90% H2O-0.1% TFA, Solvent B=90% MeOH-10% H2O-0.1% TFA, Start % B=0, Final % B=100, Gradient time=2 min, Stop time=3 min, Flow Rate=4 ml/min, Column: Xterra MS 7 um, C18, 3.0×50 mm; (ES+) m/z (M+H)+=564.36, HPLC Rt=1.768 min.

Workup

  1. customB=100, Gradient time=2 min
  2. customtime=3 min, Flow Rate=4 ml/min, Column

Sources & evidence

ORD record
ord-7c4e7def3eb9458190229221c92a55de
Source dataset
uspto-grants-2011_08
Patent number
US07994171B2

Reaction notes

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