HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-Thiazolecarboxaldehyde, 5-methyl-, oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 5-Methyl-1,3-thiazole-2-carbaldehyde | HCID 13968795 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Thiazolecarboxaldehyde, 5-methyl-, oxime | HCID 136249864 | — |
Reaction Steps
To a solution of 5-methylthiazole-2-carbaldehyde (6.1 g, 48 mmol) in EtOH (30 mL), was added pyridine (4 mL, 49 mmol) and HONH2.HCl (3.3 g, 47 mmol). The mixture was stirred at ambient temperature for 12 hours. The reaction mixture was diluted with DCM and extracted with water. The organic solution was dried, filtered and concentrated to give the crude oxime. Yield: 6 g LCMS: (ES+) m/z=143.8 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07994171B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-090d5766b7a840a09f482ed0038b4b65 |
| Source note | uspto-grants-2011_08 |