反应详情

温度

85 °C

15.0 g 2-chloro-N-(2,2-dimethoxy-ethyl)-N-methyl-acetamide in 80 ml acetonitrile are added dropwise within one hour to a suspension of 10.6 g (trans)-4-aminocyclohexanol, 16.25 g sodium carbonate and 0.64 g potassium iodide in 220 ml acetonitrile which has been warmed to 85° C. The mixture is stirred for one hour at 85° C. and for 16.5 hours at ambient temperature. It is filtered off and the filtrate is evaporated down. The residue is purified by chromatography and then recrystallised from methyl-tert-butylether and cyclohexane.

1. filtrationIt is filtered off
2. customthe filtrate is evaporated down
3. customThe residue is purified by chromatography
4. customrecrystallised from methyl-tert-butylether and cyclohexane