HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 8-(4-Methyl-3-oxo-piperazin-1-yl)-1,4-dioxa-spiro[4,5]decane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1,4-Dioxaspiro[4.5]decan-8-one | HCID 567415 | — |
| Reactant | 1-Methylpiperazin-2-one | HCID 4399042 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-(4-Methyl-3-oxo-piperazin-1-yl)-1,4-dioxa-spiro[4,5]decane | HCID 59158191 | — |
Reaction Steps
26.18 g Sodium triacetoxyborohydride are added at 5° C. to a solution of 10.0 g 4-methyl-3-oxo-piperazine, 13.51 g 1,4-dioxa-spiro[4,5]decan-8-one, 5.65 ml acetic acid and 200 ml dichloromethane. After 23 hours stirring at ambient temperature 100 ml dichloromethane and 100 ml 4N sodium hydroxide solution are added. The phases are separated and the organic phase is evaporated down. The residue is purified by chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07998949B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-a4429f6a75464374901cdeafce5ea91b |
| Source note | uspto-grants-2011_08 |