HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 178486842, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Benzyl-6-hydroxy-7-methoxyquinazolin-4-one | HCID 16734939 | — |
| Reactant | HCID 178481022 | HCID 178481022 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 178486842 | HCID 178486842 | — |
Reaction Steps
650 mg (cis)-1-methanesulphonyloxy-4-(4-methyl-3-oxo-piperazin-1-yl)-cyclohexane in 3 ml N-methyl-2-pyrrolidinone are added dropwise at 120° C. over two hours to 632 mg 3-benzyl-3,4-dihydro-4-oxo-6-hydroxy-7-methoxy-quinazoline and 1.09 g caesium carbonate in 4 ml N-methyl-2-pyrrolidinone. The product is isolated by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07998949B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-3f99220c88c54171918dae5a40fbf1cf |
| Source note | uspto-grants-2011_08 |