HCID 67335596, compound → HCID 67335638, compound

Participants

Reaction Steps

A mixture of {[1-(1H-indazol-5-ylamino)-cyclohexylmethyl]-amino}-acetic acid ethyl ester (0.808 g, 2.45 mmol) in 2N HCl (11 mL) was heated at reflux for 17 hours, then cooled to room temperature and quenched by the careful addition of K2CO3 until no more effervescence was observed. The resulting mixture was extracted with DCM and the combined extracts were dried (MgSO4), filtered and concentrated in vacuo to furnish 1-(1H-indazol-5-yl)-1,4-diaza-spiro[5.5]undecan-2-one (0.350 g, 1.23 mmol, 50%) as a solid that was used directly without further purification.

Provenance & Evidence