Aluminium lithium hydride → HCID 67336208, compound

Participants

Reaction Steps

To a stirred solution of 1-(1H-indazol-5-ylamino)-cyclobutanecarboxylic acid ethyl ester (1.68 g, 6.49 mmol) in THF (37 mL) at 0° C. and under nitrogen was added LiAlH4 (13.0 mL of a 1.0 M solution in THF, 13.0 mmol) dropwise over 2 minutes then the reaction mixture was warmed to ambient temperature. After 2 hours the reaction mixture was quenched by the addition of sodium sulfate decahydrate (2 g). The reaction mixture was filtered and the filter cake washed with EtOAc. The combined filtrates were concentrated in vacuo to a yellow solid. Purification by chromatography (silica, 4 to 20% of a 9:1 MeOH:NH4OH solution in DCM) gave [1-(1H-indazol-5-ylamino)-cyclobutyl]-methanol (0.827 g, 3.81 mmol, 59%) as a white powder.

Provenance & Evidence