Ammonia → HCID 67335038, compound

Participants

Reaction Steps

A solution of methanesulfonic acid 1-(1H-indazol-5-ylamino)-cyclobutylmethyl ester (1.31 g, ca. 3.18 mmol) in 7N NH3 in methanol (40 mL) was heated at 75° C. in a sealed tube. After 14 hours the reaction mixture was cooled to ambient temperature, concentrated in vacuo to a gum, then purified by chromatography (silica, 0 to 20% of a 9:1 MeOH:NH4OH solution in DCM) to furnish (1-aminomethyl-cyclobutyl)-(1H-indazol-5-yl)-amine (0.266 g, 1.23 mmol, 39%) as a foam.

Provenance & Evidence