Potassium Cyanide → HCID 67335728, compound

Participants

Reaction Steps

A solution of 2-(1H-indazol-5-ylamino)-hexanoic acid ethyl ester (1.0 g, 3.63 mmol) and KCN (0.026 g, 0.363 mmol) in 7N NH3 in methanol (10.4 mL) was heated at 80° C. in a sealed tube. After 96 ours the reaction mixture was cooled to ambient temperature, concentrated in vacuo, and purified by chromatography (silica, 0 to 10% MeOH in DCM) to furnish 2-(1H-indazol-5-ylamino)-hexanoic acid amide (0.647 g, 2.63 mmol, 72%) as a foam.

Provenance & Evidence