反应详情

A solution of methyl 4-methoxy-2-nitrobenzoate (9.0 g, 43 mmol) in MeOH (100 mL) was degassed and purged with nitrogen. To this solution was added 10% palladium hydroxide on carbon (1.2 g). The reaction mixture was degassed, purged with hydrogen and allowed to stir at rt overnight. The reaction mixture was filtered through Celite®, the Celite was washed with MeOH and the filtrate was concentrated to give methyl 2-amino-4-methoxybenzoate (7.80 g, 76%) as a brown solid. LCMS (FA): m/z=182.1 (M+H).

1. custompurged with nitrogen
2. additionTo this solution was added 10% palladium hydroxide on carbon (1.2 g)
3. customThe reaction mixture was degassed
4. custompurged with hydrogen
5. filtrationThe reaction mixture was filtered through Celite®
6. washthe Celite was washed with MeOH
7. concentrationthe filtrate was concentrated