HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzofuran-2-carboxylic acid → HCID 67332297, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzofuran-2-carboxylic acid | HCID 10331 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 67333061 | HCID 67333061 | — |
| Product | HCID 67332297 | HCID 67332297 | 40.1% |
Reaction Steps
BOP coupling of 2-[(4′-Amino-biphenyl-4-carbonyl)-amino]-pentanedioic acid di-tert-butyl ester (349 mg, 0.77 mmol) with 2-Benzofuran carboxylic acid (124 mg, 0.77 mmol, 1 equiv.) was carried out according to procedures in step A of Example 6B to give 185 mg of 2-({4′-[(Benzofuran-2-carbonyl)-amino]-biphenyl-4-carbonyl}-amino)-pentanedioic acid di-tert-butyl ester in 40% yield. MS (ESI) m/z 597.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07998965B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-14c7eae662ee4dfea3387a20ac1728b4 |
| Source note | uspto-grants-2011_08 |