1,1'-Carbonyldiimidazole → 5-(4-(N-trifluoroacetyl-2-aminoethoxy)but-2-yn-1-yl)-2',3' dideoxyuridine-5'-triphosphate

Participants

Reaction Steps

Without being limiting in any way, monophosphate (6) can optionally be formed by treatment of 5-(4-(N-trifluoroacetyl-2-aminoethoxy)but-2-yn-1-yl)-2′,3′dideoxyuridine (5) with, for example, POCl3. 5-(4-(N-trifluoroacetyl-2-aminoethoxy)but-2-yn-1-yl)-2′,3′-dideoxyuridine-5′-monophosphate (6) can then optionally be treated with, for example, carbonyldiimidazole (CDI) followed by tetrabutylammonium pyrophosphate (TBAPP) under appropriate conditions to form 5-(4-(N-trifluoroacetyl-2-aminoethoxy)but-2-yn-1-yl)-2′,3′-dideoxyuridine-5′-triphosphate (7). It will be recognized by one of skill in the art that conversion of 5-(4-(N-trifluoroacetyl-2-aminoethoxy)but-2-yn-1-yl)-2′,3′dideoxyuridine (5) to triphosphate (7) can be accomplished by any method known in the art.

Provenance & Evidence