Nitric Acid → HCID 178526772, compound

Participants

Reaction Conditions

Reaction Steps

20 g (0.111 mol) 7-chloro-quinolin-4-ol (Aldrich) are added during 5 min to 200 ml nitric acid (66%) heated at 85-90° C. After 4.5 h the title compound starts to precipitate as a crystalline solid. The reaction mixture is stirred for a total of 5.5 h. The hot mixture is filtered off, and the residue washed first with conc. nitric acid, then with boiling water followed by acetone. Additional material can be isolated from the mother liquors. The solid materials are combined and heated in boiling methanol for 3 h to dissolve some un-reacted starting material. The insoluble title compound is filtered off and dried for 16 h at 70° C. (high vacuum). mp: >300° C., MS: 225 (M++1); HPLC: tret=7.30 min (Grad 1).

Provenance & Evidence