Ethyl orthoformate → HCID 10356351, compound

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Reaction Steps

200 mg (0.74 mmol) 6-fluoro-N4-(2-fluoro-phenyl)-quinoline-3,4-diamine (Example 19e) in 8 ml triethylorthoformate are heated at 160° C. for 3 h. The cold solution is evaporated to dryness, and the residue is dissolved in hot ethyl acetate. By adding hexane to this solution, the title compound precipitates. The compound is filtered off and dried overnight at 60° C. (high vacuum). mp: 162-163° C.; MS: 282 (M*+1); HPLC: tret=7.26 min (Grad 1).

Provenance & Evidence