HCID 11722607, compound → HCID 10403048, compound

Participants

Reaction Steps

300 mg (0.98 mmol) of 3-(8-chloro-imidazo[4,5-c]quinolin-1-yl)-benzonitrile (Example 35) in 20 ml methanol/NH3 10% and 250 mg Raney-Ni are hydrogenated at rt for 5 h. The reaction solution is filtered on Hyflo® Super Cel diatomaceous earth and is evaporated to dryness. The title compound is crystallized from ethyl acetate-hexane to yield a grey powder. Drying is done for 16 h at 60° C. (high-vacuum). mp: 148-149° C.; MS: 309 (M++1); HPLC: tret=8.87 min (Grad 3).

Provenance & Evidence