Sodium Hydroxide → 5-Hydroxy-2-nitrobenzoic acid

Participants

Reaction Steps

124.6 g (0.618 mol) of 5-chloro-2-nitro-benzoic acid (Fluka Buchs, Switzerland) are heated under reflux in an aqueous sodium hydroxide solution [197.8 g (4.94 mol) of NaOH in 1.23 l water] for 18 h. The cold reaction mixture is extracted several times with ether-ethyl acetate, washed with brine and dried over sodium sulfate. The raw material is crystallized from isopropyl ether-hexane. The crystals are filtered off and dried at 50° C. (high-vacuum). mp: 167-171° C.; MS: 182 (M+−1); HPLC: W-=6.315 min (Grad 1).

Provenance & Evidence