5-Methoxy-2-nitrobenzoic acid → 5-Methoxyanthranilic acid

Participants

Reaction Steps

17 g (86 mmol) of 5-methoxy-2-nitro-benzoic acid (Example 44c) in 170 ml ethanol are hydrogenated (1.013 bar) over 0.85 g Pd—C 10% for 8 h at ambient temperature. The catalyst is filtered off and ca. 50 ml 1N HCl are added. By evaporating the solvent, crystals start to precipitate. Crystallization is done from ethanol-diethyl ether. The compound is collected by filtration and dried at 50° C. (high vacuum). mp: 143-148° C.; MS: 166 (M+−1); HPLC: tret=7.42 min (Grad 3).

Provenance & Evidence