HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 4-Chloro-6-methoxy-3-nitroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 178487956 | HCID 178487956 | — |
| Product | 4-Chloro-6-methoxy-3-nitroquinoline | HCID 10752457 | — |
Reaction Steps
The title compound is prepared in analogy to Example 19c starting from 3.5 g (15.89 mmol) 6-methoxy-3-nitro-quinolin-4-ol (Example 44f) and 24 ml POCl3. mp: 281-283° C.; MS: 239 (M++1); HPLC: t-=12.29 min (Grad 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07998972B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-cf35e7bfeadc485ea39ebf3665b6717e |
| Source note | uspto-grants-2011_08 |