HCID 10405339, compound → HCID 10427957, compound

Participants

Reaction Steps

To 100 mg of (0.288 mmol) 2-(8-phenyl-imidazo[4,5-c]quinolin-1-yl)-benzonitrile (Example 63) in 2 ml THF and 6 ml 10% ammonia in methanol are added ca. 50 mg Raney-Ni in ethanol. The solution is hydrogenated at rt for 6 h. The catalyst is filtered off and the raw material is purified by chromatography on silica gel (CH2Cl2-methanol 9:1) and crystallization (ethyl-acetate-hexane). mp: 163-1650° C.; MS: 351 (M++1); HPLC: tret=6.42 min (Grad 1).

Provenance & Evidence