HCID 9977862, compound → HCID 10449844, compound

Participants

Role	Name	HCID	Charge
Reactant	HCID 9977862	HCID 9977862	—
Reactant	HCID 178418546	HCID 178418546	—
Catalyst	Ferrocene-1,1'-bis-(diphenylphosphine)	HCID 635956	—
Catalyst	Tetraethylammonium cyanide	HCID 3014735	—
Catalyst	Palladium, tris[mu-[(1,2-eta:4,5-eta)-(1E,4E)-1,5-diphenyl-1,4-pentadien-3-one]]di-, compd. with trichloromethane (1:1)	HCID 11029508	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 10449844	HCID 10449844	—

Reaction Conditions

Temperature	140 °C

Reaction Steps

In an alternative way, the title compound is prepared from 2-bromo-8-chloro-1-(2-chloro-phenyl)-1H-imidazo[4,5-c]quinoline (50 mg, 0.13 mmol; Example 82), CuCN (68 mg, 0.76 mmol; Fluka, Buchs, Switzerland), tris(dibenzylideneacetone)dipalladium chloroform adduct (Pd2(dba)3.CHCl3; 20 mg, 0.02 mmol; Aldrich), 1,1′-bis(diphenylphosphino)ferrocene (DPPF; 45 mg, 0.08 mmol; Aldrich), and tetraethylammonium cyanide (40 mg, 0.25 mmol; Fluka, Buchs, Switzerland) in 5 ml 1,4-dioxane by heating the reaction mixture for 5 h at 140° C. in a sealed tube.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07998972B2
Source dataset	uspto-grants-2011_08
ORD ID	ord-cacd1eb95f2a4ab09f67cad597a937ef
Source note	uspto-grants-2011_08