Hydrochloric Acid → HCID 10339105, compound

Participants

Reaction Conditions

Reaction Steps

352 mg (0.91 mmol) of 2-[8-chloro-1-(2-chloro-phenyl)-1H-imidazo[4,5-c]quinolin-2-yl]-N-hydroxy-acetamidine (Example 87), 0.91 ml 1N HCl, in 7.1 ml water are hydrogenated at rt (tlc-control) in the presence of ca. 190 mg Raney-Ni. The catalyst is filtered off and washed with methanol. The solvents are evaporated, the residue is dissolved in CH2Cl2-water-methanol. The two phases are separated and evaporated. From the water phase, a yellow oil separates. The oil is dissolved in hot methanol and diethyl ether is added. On stirring at 0-5° C., a solid separates. The solid, which is the title compound, is filtered off and dried for 6 h at 50° C. MS: 370 (M++1); HPLC: tret=7.38 min (Grad 1).

Provenance & Evidence