Dimethylformamide → HCID 67355077, compound

Participants

Reaction Steps

To a stirred solution of methyl (benzyl{[1-(iodomethyl)cyclopropyl]methyl}amino)acetate (0.10 g, 0.00027 mol) in DMF (2.0 mL, 0.026 mol) at RT was added sodium hydride (16 mg, 0.00040 mol). The reaction mixture was stirred at RT for 1 h to achieve the desired cyclization and hydrolysis of the methyl ester. The reaction was quenched by the addition of water and acidified with 1 N HCl to pH 3-4 and washed with EtOAc. The aqueous layer was concentrated in vacuo to afford the desired product as a yellow solid, which was used in the next step without purification. LC/MS: m/e 232.2 (M+1H)+.

Provenance & Evidence