Dimethylformamide → HCID 24759086, compound

Participants

Reaction Steps

To a mixture of 5-benzyl-5-azaspiro[2.4]heptane-6-carboxylic acid (62.0 mg, 0.000268 mol) dissolved in DMF (1.0 mL, 0.013 mol) was added cyclohexanamine (30.7 μL, 0.000268 mol), benzotriazol-1-yloxytris(dimethylamino) phosphonium hexafluorophosphate (130 mg, 0.00029 mol) and TEA (0.25 mL, 0.0018 mol). After stirring at RT for 1 h, the reaction mixture was quenched with saturated aqueous NaHCO3 and extracted with EtOAc. The extracts were washed with brine, then dried (MgSO4), filtered and concentrated in vacuo. The crude material was purified by prep.-LC/MS to afford the desired product as a white solid. LC/MS: m/e 313.2 (M+1H)+.

Provenance & Evidence