1,2-Dichloroethane → HCID 24759087, compound

Participants

Reaction Steps

To a solution of N-cyclohexyl-5-azaspiro[2.4]heptane-6-carboxamide (10.0 mg, 0.0000450 mol) in 1,2-dichloroethane (0.5 mL, 0.006 mol) was added isobutyraldehyde (4.9 μL, 0.000054 mol), TEA (10 μL, 0.00009 mol), and sodium triacetoxyborohydride (20 mg, 0.00009 mol). After stirring for 30 min. at RT, the reaction mixture was quenched with saturated aqueous NaHCO3 and extracted with EtOAc. The combined organic extracts were washed with brine, then dried (MgSO4), filtered and concentrated in vacuo. The concentrate was purified by prep.-LC/MS to afford the desired product. LC/MS: 279.3 (M+H)+.

Provenance & Evidence