(Diethylamino)sulfur trifluoride → HCID 67355809, compound

HRID 1672397Notes

Reaction equation

HRID 1672397 reaction equation
[CH:1]1([N:7]2[CH2:33][CH2:32][C:9]3([N:13]([CH2:14][C:15]4[CH:20]=[CH:19][C:18]([C:21]5[CH:22]=[CH:23][C:24]([C:27]([NH:29][CH3:30])=[O:28])=[N:25][CH:26]=5)=[CH:17][CH:16]=4)[CH2:12][C@H:11](O)[CH2:10]3)[C:8]2=[O:34])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(S(F)(F)[F:41])CC)C>>[CH:1]1([N:7]2[CH2:33][CH2:32][C:9]3([N:13]([CH2:14][C:15]4[CH:20]=[CH:19][C:18]([C:21]5[CH:22]=[CH:23][C:24]([C:27]([NH:29][CH3:30])=[O:28])=[N:25][CH:26]=5)=[CH:17][CH:16]=4)[CH2:12][C@@H:11]([F:41])[CH2:10]3)[C:8]2=[O:34])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 123472(Diethylamino)sulfur trifluorideHCID 67356524HCID 67356524, compound

Product 1

HCID 67355809HCID 67355809, compound

Procedure

5-(4-{[(3R)-7-Cyclohexyl-3-hydroxy-6-oxo-1,7-diazaspiro[4.4]non-1-yl]methyl}phenyl)-N-methylpyridine-2-carboxamide (prepared according to a procedure analogous to that described for the synthesis of Example 42) was treated with diethylaminosulfur trifluoride as outlined in the synthesis of Example 81 to afford the desired product. LC/MS: 465.2 (M+1H)+.

Workup

  1. customthat described for the synthesis of Example 42)
  2. customas outlined in the synthesis of Example 81

Sources & evidence

ORD record
ord-ae6969befb1145cdadc7bd220df55a38
Source dataset
uspto-grants-2011_08
Patent number
US07998959B2

Reaction notes

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