Acetyl chloride → Acetamide, N-(2-methoxyphenyl)-

Participants

Reaction Conditions

Reaction Steps

Ortho anisidine (0.67 moles, 82 g.) was taken in a 1 L round bottom flask equipped with a liquid addition funnel and a guard tube; triethylamine (1.0 mole, 100 g) was added to it in one lot. Above mixture was cooled to 0-5° C. and acetyl chloride was added drop-wise maintaining temperature below 10° C. After addition of acetyl chloride cooling was removed and the reaction mixture was stirred at 25-28° C. for 0.3 hours. After the completion of reaction (TLC), the reaction mixture was poured on ice-water, and aqueous layer was extracted with dichloromethane (2×300 mL). The combined dichloromethane extracts were then washed with water, brine and dried over anhydrous magnesium sulfate. The volatiles were removed under the reduced pressure to obtain 96.5 g. of solid.

Provenance & Evidence