反应详情

To the solution of trans-4-({8-[1-(methylsulfonyl)-4,5-dihydro-1H-pyrrol-3-yl]quinazolin-2-yl}amino)cyclohexanol (88 mg, 0.23 mmol) in methanol (8 mL) was added 20 mg of Pd/C (dry, 10%). The mixture was hydrogenated with a H2 balloon at RT for 48 h. The catalyst was filtered off and washed with methanol (15 mL). The filtrate was concentrated in vacuo, and the residue was purified by chromatography (eluting with DCM, then DCM/EA=2/1) to give the title compound as off white solid (52 mg, 62%). 1H-NMR (CDCl3, 400 MHz): δ 8.97 (s, 1H), 7.61 (d, J=7.6 Hz, 1H), 7.59 (d, J=7.6 Hz, 1H), 7.21 (dd, J=7.6, 7.6 Hz, 1H), 5.17 (d, J=6.8 Hz, 1H), 4.30-4.25 (m, 1H), 4.01 (dd, J=9.2, 7.6 Hz, 1H), 4.01-3.98 (m, 1H), 3.71-3.67 (m, 2H), 3.54-3.50 (m, 1H), 2.92 (s, 3H), 2.49-2.29 (m, 2H), 2.28-2.24 (m, 2H), 2.12-2.06 (m, 2H), 1.57-1.50 (m, 2H), 1.45-1.30 (m, 2H). MS (m/e) 391.3 (M+1).

1. filtrationThe catalyst was filtered off
2. washwashed with methanol (15 mL)
3. concentrationThe filtrate was concentrated in vacuo
4. customthe residue was purified by chromatography (
5. washeluting with DCM