Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | tert-Butyl N-(2-chloroethyl)-N-methylcarbamate | HCID 59840485 | — |
| Reactant | HCID 178515847 | HCID 178515847 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178484427 | HCID 178484427 | — |
Reaction Steps
To the flask were added 4-{2-[(trans-4-hydroxycyclohexyl)amino]quinazolin-8-yl}phenol (110 mg, 0.33 mmol), Cs2CO3 (1345 mg, 4.13 mmol), tert-butyl (2-chloroethyl)methylcarbamate (290 mg, 1.45 mmol) and DMF (5 mL). The mixture was stirred for 3 hours at 85° C. The reaction was completed as judged by TLC. The mixture was concentrated in vacuo to afford crude tert-butyl [2-(4-{2-[(trans-4 hydroxycyclohexyl)amino]quinazolin-8-yl}phenoxy)ethyl]methylcarbamate
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07998978B2 |
|---|
| Source dataset | uspto-grants-2011_08 |
|---|
| ORD ID | ord-03c66221ae904dea953d0f96aa7e017a |
|---|
| Source note | uspto-grants-2011_08 |
|---|
