HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Hydroxy-4-methyl-2-nitrobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3-Acetamido-4-methyl-2-nitrobenzoic acid | HCID 243433 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Hydroxy-4-methyl-2-nitrobenzoic acid | HCID 81374 | 93.4% |
Reaction Steps
A solution of 3-(acetylamino)-4-methyl-2-nitrobenzoic acid (237.5 g, 0.997 mol) and KOH (451.2 g, 8.04 mol) in water (2830 mL) was refluxed for 48 h. The dark red solution was cooled and acidified to pH 1 with concentrated HCl. The yellow solid was filtered and re-crystallized from water (1800 mL) to give the title compound (183 g, 93.4%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07998978B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-38c31f1419744cd699942a50b6d9a0af |
| Source note | uspto-grants-2011_08 |