3,4-Difluorobenzaldehyde → 3-Fluoro-4-methanesulfonylbenzaldehyde

Participants

Reaction Steps

Methane sulfinic acid sodium salt (20.1 g, 200 mmol) was added to a stirred solution of 3,4-difluorobenzaldehyde (22.5 g, 158 mmol) in dry DMSO (200 ml) at 75° C. After 2 hours the reaction was poured onto ice-water (200 ml). The precipitate was filtered, washed with water and dissolved in chloroform (400 ml). The organic extract was washed with water (2×200 ml), dried over MgSO4, filtered, and the solvent removed to give the title compound as a white solid.

Provenance & Evidence