2-Fluoroethyl bromide → HCID 86634503, compound

HRID 1672510Notes

Reaction equation

HRID 1672510 reaction equation
[CH:1]1[N:2]=[CH:3][N:4]2[C:9]=1[CH2:8][CH2:7][NH:6][C:5]2=[O:10].[Br:11][CH2:12][CH2:13][F:14]>C(#N)C>[Br-:11].[F:14][CH2:13][CH2:12][N+:2]1[CH:1]=[C:9]2[N:4]([C:5](=[O:10])[NH:6][CH2:7][CH2:8]2)[CH:3]=1

Participants

4

Reactant 2

HCID 129822-Fluoroethyl bromideHCID 14875185H,6H,7H,8H-imidazo(1,5-c)pyrimidin-5-one

Product 1

HCID 86634503HCID 86634503, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
160 °C

Procedure

7,8-Dihydro-6H-imidazo[1,5-c]pyrimidin-5-one (0.45 g, 3.28 mmol) was suspended in acetonitrile (4 ml) and 1-bromo-2-fluoroethane (0.326 ml, 4.38 mmol) added. The reaction mixture was heated in a microwave reactor at 160° C. for 1 hour, then the solvent evaporated and the crude reaction mixture purified by silica chromatography eluting with dichloromethane:methanol 9:1 to afford the titled compound.

Workup

  1. customthe solvent evaporated
  2. customthe crude reaction mixture
  3. custompurified by silica chromatography
  4. washeluting with dichloromethane:methanol 9:1

Sources & evidence

ORD record
ord-66684e14b4c54a678a139327b02e5b7c
Source dataset
uspto-grants-2011_08
Patent number
US07998990B2

Reaction notes

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