Thiourea → 5-[2-Amino-5-(4-chlorophenyl)-1,3-thiazol-4-yl]-N,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)-phenyl]-1,2-dihydropyridine-3-carboxamide

Participants

Reaction Conditions

Reaction Steps

Thiourea (8.5 mg, 0.11 mmol) was added to 5-[bromo(4-chlorophenyl)acetyl]-N,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide (SM4, mg, 55 mmol) in acetonitrile (1 ml) and the mixture was heated in a microwave oven to 120° C. for 10 min. The crude product was purified on an Xterra C8 column using a gradient of acetonitrile/water. Freeze drying of the mixture afforded the title compound (10 mg, 35%).

Provenance & Evidence