反应详情

温度

100 °C

1-(4-Chloro-phenyl)-5-tributylstannanyl-1H-pyrazole (0.107 g, 0.22 mmol), 5-iodo-6-methyl-2-oxo-1-(3-trifluoromethyl-phenyl)-1,2-dihydro-pyridine-3-carboxylic acid methylamide (0.05 g, 0.11 mmol), Pd(PBut3)2 (10 mg) and DME (2 ml) were placed in a tube for microwave synthesis. The mixture was degassed with argon and heated in a synthesis microwave heater (CEM) at 100° C. (max 150 W) for 10 minutes. The solvent was removed in vacuo giving a crude product which was purified on silica and then further purified on preparative HPLC. The pure fractions were freeze-dried giving 10 mg (17%) of the title compound.

1. customThe mixture was degassed with argon
2. customThe solvent was removed in vacuo
3. customgiving a crude product which
4. customwas purified on silica
5. customfurther purified on preparative HPLC
6. customThe pure fractions were freeze-dried