4-(5-Tributylstannanyl-[1,2,3]triazol-1-yl)-benzonitrile → 5-[3-(4-Cyano-phenyl)-3H-[1,2,3]triazol-4-yl]-6-methyl-2-oxo-1-(3-trifluoromethyl-phenyl)-1,2-dihydro-pyridine-3-carboxylic Acid Methylamide

Participants

Reaction Conditions

Reaction Steps

4-(5-Tributylstannanyl-[1,2,3]triazol-1-yl)-benzonitrile (0.107 g, 0.22 mmol), 5-iodo-6-methyl-2-oxo-1-(3-trifluoromethyl-phenyl)-1,2-dihydro-pyridine-3-carboxylic acid methylamide (0.05 g, 0.11 mmol), Pd(PBut3)2 (10 mg) and DME (2 ml) were placed in a tube for microwave synthesis. The mixture was degassed with argon and heated in a synthesis microwave heater (CEM) at 100° C. (max 150 W) for 10 minutes. The solvent was removed in vacuo giving a crude product which was purified on silica and then further purified on preparative HPLC. The pure fractions were freeze-dried giving 20 mg (40%) of the title compound.

Provenance & Evidence