反应详情

温度

120 °C

5-[(4-Chlorophenyl)ethynyl]-N,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide (111 mg, 0.25 mmol) was mixed with formic acid (1 ml) and heated in a microwave oven to 120° C. for 1 h. The formic acid was evaporated off and the residue was purified on an Xterra C8 column using a gradient of acetonitrile/water. Freeze drying of the mixture afforded 5-[(4-chlorophenyl)acetyl]-N,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide (77 mg, 66%).

1. customThe formic acid was evaporated off
2. customthe residue was purified on an Xterra C8 column
3. customFreeze drying of the mixture