3-bromo-N-(2-hydroxy-1,1-dimethylethyl)benzenesulfonamide → 3-[5-(4-Chloro-3-methyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamide

HRID 167261Notes

Reaction equation

HRID 167261 reaction equation
[Br:24][c:25]1[cH:26][c:27]([S:31](=[O:32])(=[O:33])[NH:34][C:35]([CH2:36][OH:37])([CH3:38])[CH3:39])[cH:28][cH:29][cH:30]1.[Cl:1][c:2]1[c:3]([CH3:23])[cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([C:14]([F:15])([F:16])[F:17])[cH:13]2)[n:18][cH:19][c:20]3[C:21]#[CH:22])[cH:6][cH:7]1>>[Cl:1][c:2]1[c:3]([CH3:23])[cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([C:14]([F:15])([F:16])[F:17])[cH:13]2)[n:18][cH:19][c:20]3[C:21]#[C:22][c:25]2[cH:26][c:27]([S:31](=[O:32])(=[O:33])[NH:34][C:35]([CH2:36][OH:37])([CH3:38])[CH3:39])[cH:28][cH:29][cH:30]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 435019003-bromo-N-(2-hydroxy-1,1-dimethylethyl)benzenesulfonamideHCID 866080535-(4-Chloro-3-methyl-phenyl)-3-ethynyl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 670007043-[5-(4-Chloro-3-methyl-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzenesulfonamide

Sources & evidence

ORD record
ord-ad97f829de364944b5b4e3ae08cc5b64
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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