反应详情

7 g (30.56 mmol) of ethyl 4-bromobenzoate are dissolved in 60 ml of 1,2-dimethoxyethane and, under argon, 6.96 g (36.67 mmol) of 4-trifluoromethylphenylboronic acid, 271 mg of bis(triphenylphosphine)palladium(II) chloride and 40.7 ml of a 2 M solution of sodium carbonate in water are added. The reaction mixture is then heated under reflux for 12 hours. The mixture is subsequently cooled, filtered through 1 g of Extrelut, washed with dichloromethane and concentrated. The crude product is purified by flash chromatography on silica gel (mobile phase: cyclohexane/dichloromethane 2:1). 6.31 g (21.4 mmol, 70% yield) of a colorless solid are obtained.

1. temperatureThe reaction mixture is then heated
2. temperatureunder reflux for 12 hours
3. temperatureThe mixture is subsequently cooled
4. filtrationfiltered through 1 g of Extrelut
5. washwashed with dichloromethane
6. concentrationconcentrated
7. customThe crude product is purified by flash chromatography on silica gel (mobile phase: cyclohexane/dichloromethane 2:1)