Triphenylphosphine → {2-[Difluoro-(4'-trifluoromethylbiphenyl-4-yl)methoxy]-5-fluorobenzyl}triphenylphosphonium bromide

Participants

Reaction Steps

217 mg (0.46 mmol) of 2-(bromomethyl)-4-fluorophenyl difluoro[4′-(trifluoromethyl)biphenyl-4-yl]methyl ether from Example 41A and 148 mg (0.57 mmol) of triphenylphosphine are stirred in 5 ml of THF at RT for 12 hours. The reaction mixture is concentrated and the residue is washed with diethyl ether and n-hexane. The crude product is employed without further purification in the subsequent stage.

Provenance & Evidence