Triphenylphosphonium bromide → [2-(2-Chlorobenzyloxy)-5-fluorobenzyl]triphenylphosphonium bromide

Participants

Reaction Steps

4.60 g (17 mmol) of [2-(2-chlorobenzyloxy)-5-fluorophenyl]methanol are dissolved in 10 ml of acetonitrile, 5.62 g (16 mmol) of triphenylphosphine hydrobromide are added, and the suspension is stirred under reflux for 12 h. A further 2.80 g (8 mmol) of triphenylphosphine hydrobromide are added, and the mixture is stirred under reflux for a further 3 h. The solvent is mostly distilled out in vacuo, and the crystals which have separated out are stirred with petroleum ether, filtered off with suction and dried on a clay dish. 9.82 g (15.7 mmol, 92% of theory) of the title compound are obtained.

Provenance & Evidence