Potassium Iodide → HCID 57864373, compound

Participants

Reaction Steps

4.44 g (26 mmol) of methyl 5-fluoro-2-hydroxybenzoate [CAS 391-92-4], 5.25 g 28.7 mmol) of 4-tert-butylbenzyl chloride [CAS 19692-45-6], 18.0 g (130 mmol) of potassium carbonate and 6.5 g (39.2 mmol) of potassium iodide are dissolved in 25 ml of acetone and stirred under reflux for 12 h. The solvent is distilled out in vacuo, and the residue is taken up in ethyl acetate and washed once with 10% strength sodium hydroxide solution and three times with 1 N hydrochloric acid. The solution is dried over sodium sulfate, filtered, washed with ethyl acetate and concentrated. 8.36 g (26 mmol, 100% of theory) of the title compound are isolated.

Provenance & Evidence