Triphenylphosphonium bromide → HCID 86634290, compound

Participants

Reaction Steps

5.80 g (20 mmol) of [2-(4-tert-butylbenzyloxy)-5-fluorophenyl]methanol are dissolved in 70 ml of acetonitrile, 6.56 g (19.5 mmol) of triphenylphosphine hydrobromide are added, and the suspension is stirred under reflux for 24 h. The solvent is mostly distilled out in vacuo, and the crystals which have separated out are stirred with diethyl ether, filtered off with suction, washed with petroleum ether and dried on a clay dish. The resulting crude product is purified by preparative HPLC. 2.64 g (4.3 mmol, 21% of theory) of the title compound are obtained.

Provenance & Evidence