Hydrochloric Acid → 2-(4-(Trifluoromethyl)phenyl)ethan-1-ol

Participants

Reaction Steps

3.0 g (14.7 mmol) of 4-trifluoromethylphenylacetic acid are introduced into 30 ml of abs. THF at 0° C. A 1 M solution of 557.8 mg (14.7 mmol) of lithium aluminum hydride in 14.7 ml of THF is added dropwise, and the solution is stirred at room temperature until reaction is complete. The mixture is added to ice, acidified with hydrochloric acid and extracted with ethyl acetate. The organic phase is concentrated, and the crude product is purified by chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 6:1). 2 g (92% of theory) of the title compound are obtained.

Provenance & Evidence