Hydrochloric Acid → 5-Fluoro-2-[2-(4-trifluoromethylphenyl)ethoxy]benzyl alcohol

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Reaction Steps

2.0 g (5.84 mmol) of methyl 5-fluoro-2-[2-(4-trifluoromethylphenyl)ethoxy]benzoate are introduced into 25 ml of THF. At 0° C., 4.38 ml (4.38 mmol) of a 1 M lithium aluminum hydride solution in THF are added dropwise, and the mixture is stirred at RT until reaction is complete. The mixture is added to ice-water, acidified with hydrochloric acid and extracted with ethyl acetate. All the volatile components are removed in vacuo, and the crude product is purified by chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 5:1). 1.7 g (82% yield) of the title compound are obtained.

Provenance & Evidence