Carbon tetrabromide → HCID 67351737, compound

Participants

Reaction Steps

834 mg (3.18 mmol) of triphenylphosphine and 1.05 g (3.18 mmol) of tetrabromomethane are dissolved in 2 ml of THF and stirred at room temperature for 10 min. Then 860 mg (2.63 mmol) of {5-fluoro-2-[3-(4-trifluoromethylphenyl)prop-2-ynyloxy]phenyl}methanol, dissolved in 2 ml of THF, are added dropwise, and the mixture is stirred at room temperature overnight. The solvent is distilled out in vacuo, and the residue is chromatographed on silica gel (mobile phase: cyclohexane/ethyl acetate 10:1). 240 mg (0.62 mmol, 24% of theory) of 5-fluoro-2-[3-(4-trifluoromethylphenyl)prop-2-ynyloxy]benzyl bromide are obtained.

Provenance & Evidence