反应详情

A solution of 3.775 g (15.18 mmol) of [2-(2-chlorobenzyloxy)phenyl]methanol from Example 78A in 60 ml of acetonitrile is mixed with 4.949 g (14.42 mmol) of triphenylphosphonium hydrobromide and heated to reflux for 3 hours. The reaction solution is then concentrated to dryness, and the resulting oil is taken up and triturated in diethyl ether. The product crystallizes as a white solid during this. After filtration, the solid is dried in a drying oven at 50° C. overnight. 8.247 g (91% yield) of crystalline product are obtained.

1. temperatureheated
2. temperatureto reflux for 3 hours
3. concentrationThe reaction solution is then concentrated to dryness
4. customtriturated in diethyl ether
5. customThe product crystallizes as a white solid during this
6. filtrationAfter filtration
7. customthe solid is dried in a drying oven at 50° C. overnight