Hydrochloric Acid → HCID 135446415, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 32.7 mg (0.05 mmol) of methyl 4-[({2-[4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)phenyl]ethyl}-{2-[2-(4′-trifluoromethylbiphenyl-4-ylmethoxy)phenyl]ethyl}amino)methyl]-benzoate from Example 11A in 2 ml of THF and 2 ml of water is mixed with 2.2 mg (0.09 mmol) of lithium hydroxide and stirred at 50° C. for 12 h. After cooling, the THF is stripped off and the aqueous phase is adjusted to pH 4-5 with 1 M hydrochloric acid. It is then extracted three times with ethyl acetate, and the combined organic phases are dried over sodium sulfate. The residue obtained after filtration and concentration is purified by preparative HPLC. 7.4 mg (0.01 mmol, 23% yield) of a colorless oil are obtained.

Provenance & Evidence