Hydrochloric Acid → HCID 135979888, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 500 mg (0.81 mmol) of methyl 4-((3E)-4-{2-[(4-tert-butylbenzyl)oxy]phenyl}-2-{2-[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]ethyl}but-3-en-1-yl)benzoate in 5 ml of THF and 5 ml of water is mixed with 38.8 mg (1.62 mmol) of lithium hydroxide and stirred at 50° C. for 12 h. Cooling is followed by addition of water and extraction with diethyl ether. The aqueous phase is acidified with 1 M hydrochloric acid and extracted with diethyl ether. The resulting organic phase is washed with sodium chloride solution, dried over sodium sulfate and concentrated. 420 mg (0.7 mmol, 79% of theory) of the title compound are obtained.

Provenance & Evidence