Triethylamine → HCID 178505322, compound

Participants

Reaction Steps

Dissolve (R)-3-(4-Benzyloxy-2,6-dichloro-benzyl)-trans-1-(4-hydroxy-cyclohexyl)-pyrrolidin-2-one (1.291 g, 2.86 mmol) in 25 ml of dry dichloromethane at 0° C. Add triethylamine (0.73 ml, 5.77 mmol) followed by methanesulfonyl chloride (0.25 ml, 3.17 mmol). Stir at room temperature for 3 hours. Quench with 1N HCl and extract with ethyl acetate. Wash the extract with 1N HCl, NaHCO3 and brine. Dry over magnesium sulfate, filter, and concentrate. Purify by column chromatography to receive 1.315 g of the title compound: Mass spectrum (apci) m/z=526 (M+H).

Provenance & Evidence