HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (4,4-difluorocyclohexyl)carbamate → (4,4-Difluorocyclohexyl)amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (4,4-difluorocyclohexyl)carbamate | HCID 22175003 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | (4,4-Difluorocyclohexyl)amine | HCID 3847030 | — |
Reaction Steps
Allow the solution of (4,4-difluoro-cyclohexyl)-carbamic acid tert-butyl ester in 20 mL of TFA to stand at room temp for overnight. Concentrate the mixture under vacuum. Pass the residue through a SCX column to yield 251 mg of the title product: mass spectrum (m/z): 136 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07998999B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-458ae7ed4295430e97f2bf72e51305c1 |
| Source note | uspto-grants-2011_08 |