Sodium Carbonate → 3-(2,6-Dichloro-4-pyridin-3-yl-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one

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Reaction Steps

Heat a solution of trifluoro-methanesulfonic acid 3,5-dichloro-4-[1-(4,4-difluoro-cyclohexyl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl ester (Preparation 33) (0.585 g, 1.15 mmol), pyridine-3-boronic acid (0.283 g, 2.30 mmol), Pd(PPh3)4 (133 mg), 11.5 mL of 0.1 M Na2CO3 aq solution in 11.5 mL of dimethoxy ethane at 80° C. for 24 hr. Cool the mixture to room temp and dilute with 20 mL of 1N NaHCO3. Dilute the mixture with 20 mL of EtOAc. Wash the organic layer with water, then brine, and dry over Na2SO4, filter and concentrate. Purify the crude material by chromatography to afford the title compound: mass spectrum (m/z): 439 (M+1).

Provenance & Evidence